Confused? I ain't want none of that Eastern Philosophy, son!
Confused Will Muschamp comes from a press conference where a reporter asked him if he felt a "Padawan-Master relationship" with Nick Saban. Muschamp, having not seen any of the Star Wars movies that suck (only the original and The Empire Strikes Back) had no clue what was being asked.
Now, the picture generally accompanies wordplay confusing a word used with another similar sounding word.
There is also a variation on the meme where the picture is progressively reduced to an absurdly small size as the conversation chain continues. Stems from commenters asking to limit the size or frequency of the image, as it is typically unedited when used in Confused Muschamp context.