The Mortified Michigan Punter is perhaps the greatest sports GIF of all time. On November 26, 2011, the Michigan Wolverines faced archrival Ohio State in their final regular season game of 2011. On fourth down, Michigan punter Will Hagerup muffed a snap, causing the ball to hit off the crown of his helmet and into the backfield. Hagerup's panicked expression was captured for all to see, and the Mortified Michigan Punter meme was born.
The original GIF can be seen here. 
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